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Smart Evaporator

Hands Free Concentrator

“It worked perfectly!”

FDA lab in Cincinnati, OH

“The Smart Evaporator is effective at concentrating and drying samples in vials and centrifuge tubes.”

Professor Takuya Kumamoto

Department of Pharmaceutical Sciences Organic Chemistry, Musashino University.

“The Smart Evaporator allows me to concentrate my samples into vials in less time with no mess—even DMSO and DMF. Very convenient!”

Researcher, Novartis

“Everybody in the lab likes to use it. It saves us a lot of time!”

Biotech company in Sunnyvale, CA

“The Smart Evaporator is perfect for small samples. I have found it especially useful for recovering material from d6-DMSO NMR samples.”

Dr. Tioga Martin

Asc. Scientist, Agensys, Inc.

“I appreciate the Smart Evaporator’s ability to concentrate directly in my 2 mL sample vials bump free.”

Takeo Kurata

Researcher, Meiji University, Science and Engineering Applied Chemistry

“The Smart Evaporator has been useful for evaporating NMP. It is small and space-saving, so we can put it in a hot cell. I’m fully satisfied with the evaporation speed.”

Mr. Hiroshi Yamaguchi

Radiology Research Department, Akita Prefectural Hospital

Bump Free

The novel Spiral Plug technology generates a helical flow of air or inert gas over the surface of your solvent, thereby increasing the surface area. Since the vial isn’t under high vacuum, there is no risk of bumping or splashing.

DMSO & DMF Concentrator

The Smart Evaporator enables efficient evaporation of high boiling point solvents. With the inert gas purging feature (ex. nitrogen), it’s great for drying down solvents such as DMSO, DMF and water. (inert gas reccomended)

Sample Vessel Compatibility

The Spiral Plugs come in various sizes for compatibility with many different sample tubes, flasks, and vials.
Coupled with a quick release, the Spiral Plugs are easily exchangeable between different sizes.

Smart Evaporator C1

Single Channel Evaporator

Smart Evaporator K4

Open Type 4 Channel Evaporator

Smart Evaporator C10

10 Channel Evaporator


Bump Free

DMSO & DMF Concentrator

Sample Vessel Compatibility

Smart Evaporator C1

  • Vial of your choice
  • Easy to change vial size
  • Room temperature to 100°C
  • Nitrogen Purging Feature

Smart Evaporator K4

  • Up to 4 vials at a time
  • Easy to change vial size
  • Aluminum beads for versatile compatibility
  • Room temperature to 100°C

Smart Evaporator C10

  • Up to 10 vials at a time
  • Heat Carousel
  • Room temperature to 100°C
  • Nitrogen Purging Feature

Optional Items

Spiral Plugs

Available in 5 sizes to fit most sample vials
(each sold separately)

Vacuum Pump

Is required to operate the Smart Evaporator
(sold separately)

Cold Trap

Dewar style cold trap recommended to recapture solvent (sold separately)


Blog Entries

How can I remove DMSO from my sample?

We introduce a simple way to remove Dimethyl Sulfoxide (DMSO). DMSO is used in organic synthesis as a reaction solvent as well as analytical chemistry for NMR analysis (DMSO-D6) due to its ability to dissolve many compounds that are difficult to dissolve otherwise.  However, after a synthetic workup or NMR analysis, DMSO is difficult to remove using a traditional rotary evaporator due the the high boiling point (189°C).


To remove DMSO, a common method is to wash with water and extract with a lower boiling point organic solvent like DCM1.  Other methods involve freeze drying (lyophilization) after water dilution or solid phase extraction (SPE). However, these methods involve several transfer steps, are very time consuming with multiple washes, and can be inefficient resulting in lower yields.


An easier way has been developed to evaporate high boiling point solvents like DMSO directly in your sample vial using the Smart Evaporator. The Smart Evaporator uses a novel concentration principle of solvent removal by spiral air flow with its unique Spiral Plug design. Since there is no sample transfer required, sample loss and risks of cross-contamination are minimized.


With its nitrogen purging feature, the Smart Evaporator can remove 5mL of DMSO in just over an hour at 70°C.  In addition, since it is never under high vacuum, there is no risk of bumping, for hands-free concentration.



  1. http://chem.rochester.edu/~nvd/documents/Efficient_extraction_of_highly_polar_solvents_from_reaction_mixtures.doc

We received The Ministry of Education Award 2018 for Science and Technology


After we received the 42nd Invention Award in 2016, the Japan Society for the Advancement of Inventions recommended we apply for this award. They give this award to the people who develop superior technology. And who contribute to the development of the regional economy in small and medium enterprises and local industries.

We could have not achieved this without your support, and we are thankful for it.


Award outline


“Science and Technology Award (Technology division)


Name of Achievement: “Development of evaporator for volatile substances using spiral rotating flow”



  • (head) Kazumasa Kinoshita, Representative Director of BioChromato, Inc.
  • Takashi Oonuki, Research Promotion Group, Group Director in Research Promotion Dept of Daiichi Sankyo RD Novare CO., LTD
  • Mutsuo Nakajima Former Senior Researcher of Sankyo Co., Ltd.

We will continue to devote ourselves to develop products based on customer’s voices. We kindly ask for your continued cooperation.


The detailed information is available here* on the website of Ministry of Education.
*We apologize as it is available in Japanese only.

BioChromato at ACS 2016 in Philadelphia



BioChromato exhibited at ACS 2016 in Philadelphia this past August 21-25. We had a great show with a steady traffic of Chemists.

Our lab consumables (EPS and Slit Seal) were on display. As well as our newest Mass spectrometry products, the ionRocket and Volatimeship. However, the star of the show was our Smart Evaporator (C1 and C10).

The Charm of the Smart Evaporator


We had many interesting and great conversations with many chemists from both industry and academia. We talked about the work they are doing and we discussed how our products may ease their work. We learned a lot from them.

Several of the chemists we spoke to are working in radiochemistry working with hazardous radioactive substances.  The small size of the C1 impressed them as well as the ability to work inside a hot cell.


We also spoke to other chemists in medicinal chemistry working with small vials. They want to concentrate directly in their own sample vials. The C1 Smart Evaporator would be a great benefit for these researchers because the C1 allows direct concentrating in vials.

For synthetic organic chemists, being able to evaporate bump free is a major benefit. We heard a story about a 6 step synthesis process that resulted in a complete loss due to bumping caused by a Rotary Evaporator. A whole month’s work gone to waste.

We were also visited by many colleagues of happy customers that referred them to us. We continue to impress with its ability to evaporate bump free. Thereby reducing the risk of losing their material.

The Multi Channel Smart Evaporator


We had the Smart Evaporator C10 on display. People were able to see the multi-channel system. Their major takeaway: cross-contamination free between samples due to the vacuum technology.

There is also great interest in the C10 from teaching labs. Often, students are working on the same synthesis step and they have to fight over the only functioning Rotary Evaporator. Evaporating 10 samples at a time will reduce this bottleneck.

Thanks to everyone that stopped by. For those that were not able, we look forward to a conversation. Please feel free to contact us to learn more about how we can help streamline your research process.


Rotary Evaporator and Smart Evaporator

Rotary Evaporator

Differences between Rotary Evaporator and Smart Evaporator

Smart evaporator removes DMSO

Rotary evaporator is more efficient for most solvents. The Smart Evaporator evaporates and better removes high boiling point solvents such as DMSO, DMF and Water. Also, Smart Evaporator has advantages on small volume and precious samples regardless of the type of solution. A traditional Rotary Evaporator works better for others.

Rotary evaporators are used in chemistry laboratories for solvent removal. Including high boiling point solvents and sample concentration by using heat and vacuum. The Smart Evaporator is not intended to replace rotary evaporators. As rotary evaporators are still needed in many situations when concentrating samples. With the Smart Evaporator, you don’t need to worry about bumping during concentration of high boiling point samples. You may walk away during the concentrating process.

With a rotary evaporator, the solvent is under full vacuum to lower the boiling point. Heat is applied to the sample for the evaporation to occur. While effective, these conditions can lead to super-heating. This triggers rapid boiling, or “bumping” in your solvents. With the risk of cross-contamination upon bumping, this can lead to complete loss of the sample. Still, a rotary evaporator is a must have item for any organic chemistry lab. In conclusion, you need both types of evaporators.

No Bumping by Smart Evaporator

In contrast, the Smart Evaporator has no risk of bumping. There is no splashing in the evaporation process, since samples are never under full vacuum. Blowing is a common way to remove solvent. Putting a needle or pipette tip to a hose coming from a tank of inert gas such as helium, nitrogen, or argon gas. But, this method has drawbacks as well, as it is time consuming and leads to splashing. The Smart Evaporator provides a more elegant solution. By offering a hands-free evaporation process without the risk of bumping or splashing.