Smart Evaporator

Hands Free Concentrator

“It worked perfectly!”


FDA lab in Cincinnati, OH

“It is nice to be able to evaporate samples without having to constantly monitor it.”

Professor Richard T. Taylor

Department of Chemistry and Biochemistry, Miami University.


“The Smart Evaporator is effective at concentrating and drying samples in vials and centrifuge tubes.”

Professor Takuya Kumamoto

Department of Pharmaceutical Sciences Organic Chemistry, Musashino University.

“The Smart Evaporator allows me to concentrate my samples into vials in less time with no mess—even DMSO and DMF. Very convenient!”


Researcher, Novartis

“Everybody in the lab likes to use it. It saves us a lot of time!”


Biotech company in Sunnyvale, CA

“The Smart Evaporator is perfect for small samples. I have found it especially useful for recovering material from d6-DMSO NMR samples.”

Dr. Tioga Martin

Asc. Scientist, Agensys, Inc.

“I appreciate the Smart Evaporator’s ability to concentrate directly in my 2 mL sample vials bump free.”

Takeo Kurata

Researcher, Meiji University, Science and Engineering Applied Chemistry

“The Smart Evaporator has been useful for evaporating NMP. It is small and space-saving, so we can put it in a hot cell. I’m fully satisfied with the evaporation speed.”

Mr. Hiroshi Yamaguchi

Radiology Research Department, Akita Prefectural Hospital

Bump Free

The novel Spiral Plug technology generates a helical flow of air or inert gas over the surface of your solvent, thereby increasing the surface area. Since the vial isn’t under high vacuum, there is no risk of bumping or splashing.

DMSO & DMF Concentrator

The Smart Evaporator enables efficient evaporation of high boiling point solvents. With the inert gas purging feature (ex. nitrogen), it’s great for drying down solvents such as DMSO, DMF and water. (inert gas reccomended)

Sample Vessel Compatibility

The Spiral Plugs come in various sizes for compatibility with many different sample tubes, flasks, and vials.
Coupled with a quick release, the Spiral Plugs are easily exchangeable between different sizes.

Smart Evaporator C1

Single Channel Evaporator

Smart Evaporator K4

Open Type 4 Channel Evaporator

Smart Evaporator C10

10 Channel Evaporator


Bump Free

DMSO & DMF Concentrator

Sample Vessel Compatibility

Smart Evaporator C1

  • Vial of your choice
  • Easy to change vial size
  • Room temperature to 100°C
  • Nitrogen Purging Feature

Smart Evaporator K4

  • Up to 4 vials at a time
  • Easy to change vial size
  • Aluminum beads for versatile compatibility
  • Room temperature to 100°C

Smart Evaporator C10

  • Up to 10 vials at a time
  • Heat Carousel
  • Room temperature to 100°C
  • Nitrogen Purging Feature

Optional Items

Spiral Plugs

Available in 5 sizes to fit most sample vials
(each sold separately)

Vacuum Pump

Is required to operate the Smart Evaporator
(sold separately)

Cold Trap

Dewar style cold trap recommended to recapture solvent (sold separately)



Kato, E., Kubo, M., Okamoto, Y., Matsunaga, Y., Kyo, H., Suzuki, N., … & Fukuyama, Y. (2018). Safety Assessment of Bangle (Zingiber purpureum Rosc.) Rhizome Extract: Acute and Chronic Studies in Rats and Clinical Studies in Human. ACS Omega, 3(11), 15879-15889.

Blog Entries

NMR Solvent Selection


When selecting a solvent for running Nuclear Magnetic Resonance Spectroscopy (NMR) analysis, typically a deuterated solvent is used in order to minimize background signals and provide a lock signal to compensate for drifts in the magnetic field1.


However, there are several other factors to consider for NMR solvent selection:

  • Solubility
  • Interfering peaks
  • Price
  • Isotopic purity
  • Ease of NMR sample recovery


With these factors in mind, a common “go-to” solvent for analysis is the deuterated form of chloroform, since it is relatively inexpensive with high isotopic purity, dissolves many compounds, and is easy to evaporate after analysis for NMR sample recovery (boiling point 61.2°C)3.


However, there are cases when CDCl3 is not appropriate. In fact, there are many other solvents commonly used for NMR analysis4. Since no solvent is 100% deuterated, there will always be an observed 1H peak for the solvent, which may interfere with the compound of interest5. Additionally, solubility might be a problem leading one to empirically determine an appropriate solvent. “For 1H NMR, it is recommended to dissolve between 2 and 10 mg in between 0.6 and 1 mL of solvent so that the sample depth is at least 4.5 cm in the tube.”4 Thus, appropriate solubility must be considered in NMR solvent selection.



Compounds like DMF-d7 or DMSO-d6 have benefits to use as an NMR solvent as they are relatively inexpensive and can solubilize many compounds that are otherwise difficult to solubilize. However, in the past, it was difficult to remove these solvents due to high boiling points (153°C and 189°C), and thus running NMR with DMF or DMSO as a solvent was seen as a “dead end” for samples. This is frustrating and disheartening when forced to discard the most precious samples. However, a new instrument called Smart Evaporator has made it possible to evaporate solvents for quick NMR sample recovery, even directly in small 2 mL vials.

The Smart Evaporator uses a novel “Spiral Plug” technology to evaporate samples without any risk of bumping. It is particularly useful for high boiling point solvents like DMSO or DMF, but can also be used to dry down most organic solvents directly in a sample vial.


Here’s what our users had to say:

“The Smart Evaporator is perfect for small samples. I have found it especially useful for recovering material from DMSO-d6 NMR samples.”
– Dr. Tioga Martin, Asc. Scientist, Agensys, Inc.


“[The Smart Evaporator] is suitable for evaporation of samples previously measured by NMR.”
– Smart Evaporator User


For more information about the Smart Evaporator technology for NMR sample recovery and other dry-down applications, visit our page:



Types of Solvent Evaporators – An Overview


Removal of solvents is a common need in any organic chemistry lab and often times the major “bottleneck” in a synthetic workup, thereby slowing down production. Additionally, evaporation of solvent is required for recovery of samples analyzed by NMR spectroscopy. To accomplish this task, different types of evaporators have been developed. Herein, we provide an overview of solvent evaporators commercially available on the market.

Rotary evaporator

A rotary evaporator (rotovap) works by placing the sample under vacuum thereby lowering the boiling point of the solvent. Typically, a round bottom flask is used where it is lowered in a heated water bath. The flask is rotated to increase the surface area and provide an even transfer of heat. A rotovap is found in almost any organic chemistry lab and is a great way to quickly evaporate most volatile organic solvents. Thus, it is typically used when evaporating single volatile samples at relatively larger sample volumes. However, since the glassware is under high vacuum, there’s always a risk of the solvent superheating and boiling over or “bumping.” Once a sample boils over, there is a high risk of cross-contamination and losing material. There’s also a safety concern regarding the glassware as improper selection or defective glass could lead to an implosion. Additionally, since it can only handle a single vessel, evaporating multiple samples must be done in series, which can be time consuming.

Centrifugal evaporator

A centrifugal evaporator also works under high vacuum to lower the boiling point. However, instead of rotating the glassware, samples are placed in a multiplexed heated compartment where they are centrifuged to avoid bumping. A centrifugal evaporator is a great way to evaporate a large number of samples at once since they can accommodate multiple centrifuge tubes at a time. However, it may not be suitable for higher boiling point solvents like DMSO or water, as it can be time-consuming, typically overnight. This is particularly frustrating If you only have a few samples to evaporate, and tying up your evaporator for many hours creates a backlog of your other samples you wish to dry down. Additionally, care must be taken by the operator to ensure that the samples are well balanced and proper centrifuge tubes are used as improper glassware tends to break under centrifugal force. This can be quite problematic when working with precious samples or hazardous material.

Nitrogen blowdown evaporator

Nitrogen evaporators use a stream of nitrogen gas to continuously blow on the surface of a solvent (AKA “Nitrogen Blowdown”). This lowers the vapor pressure and increases the surface area. To accomplish this, some chemists simply connect a nitrogen gas line to a syringe to dry down a single vial. However, this is easier said than done. If the flow of nitrogen is too far away from the sample surface, the evaporation speed may be too slow. If it is placed too close, there is a risk of samples blowing over. Indeed, care must be taken for optimal results. In order to better optimize and automate the process, companies have developed nitrogen evaporators. Typically, the nitrogen gas is heated and/or a heat block is used to speed up evaporation. Since a nitrogen blowdown system can be connected to an array, nitrogen blowdown is useful when working with high number of smaller sample sizes (ex. 96 well plates). However, nitrogen blowdown is not recommended for large sample sizes, especially working with volatile or semi-volatile samples due to both time and turbulence.

Spiral Air Flow Evaporator – Smart Evaporator

A novel evaporation system offers a new means for evaporating samples in vials using a spiral air flow evaporation method. This method has been developed by BioChromato in an instrument commercially available called the Smart Evaporator. Unique Spiral Plugs are placed over the vial where it is connected to a vacuum pump. However, instead of pulling a high vacuum, as the vacuum pump aspirates the vapor above the solvent surface, the helical grooves of the Spiral Plugs draw in an influx of air or inert gas. The Spiral Plugs control the airflow over the surface of the solvent in a spiral. This both lowers the vapor pressure and increases the surface area. Meanwhile, sample vials are placed in an aluminum bead bath connected to a programmable heater up to 100°C where heat is transferred to speed up the evaporation process. There are many benefits using the Smart Evaporator. Since it is flow-based, there is no risk of bumping or splashing. Additionally, since concentration is carried out just below atmospheric pressure, there is no risk of implosion. Thus, any vial, flask, or tube that fit in the instrument are compatible, allowing direct concentration in a sample vial already being used. This can help avoid cross-contamination and result in higher yields. This is a useful method in evaporating higher boiling point solvents like DMSO, DMF, or water. A Smart Evaporator is an excellent way to evaporate high boiling point solvents directly in a sample vial. With the multiple channel models, it’s possible to evaporate up to 10 at a time.


Common NMR Solvent:

Deuterium oxide
Formic acid-d2

Trifluoroaceric acid-d

How can I remove DMSO from my sample?

We introduce a simple way to remove Dimethyl Sulfoxide (DMSO). DMSO is used in organic synthesis as a reaction solvent as well as analytical chemistry for NMR analysis (DMSO-D6) due to its ability to dissolve many compounds that are difficult to dissolve otherwise. However, after a synthetic workup or NMR analysis, DMSO is difficult to remove using a traditional rotary evaporator due the the high boiling point (189°C).

To remove DMSO, a common method is to wash with water and extract with a lower boiling point organic solvent like DCM1. Other methods involve freeze drying (lyophilization) after water dilution or solid phase extraction (SPE). However, these methods involve several transfer steps, are very time consuming with multiple washes, and can be inefficient resulting in lower yields.

An easier way has been developed to evaporate high boiling point solvents like DMSO directly in your sample vial using the Smart Evaporator. The Smart Evaporator uses a novel concentration principle of solvent removal by spiral air flow with its unique Spiral Plug design. Since there is no sample transfer required, sample loss and risks of cross-contamination are minimized.

With its nitrogen purging feature, the Smart Evaporator can remove 5mL of DMSO in just over an hour at 70°C. In addition, since it is never under high vacuum, there is no risk of bumping, for hands-free concentration.





We received The Ministry of Education Award 2018 for Science and Technology


After we received the 42nd Invention Award in 2016, the Japan Society for the Advancement of Inventions recommended we apply for this award. They give this award to the people who develop superior technology. And who contribute to the development of the regional economy in small and medium enterprises and local industries.

We could have not achieved this without your support, and we are thankful for it.


Award outline


“Science and Technology Award (Technology division)


Name of Achievement: “Development of evaporator for volatile substances using spiral rotating flow”



  • (head) Kazumasa Kinoshita, Representative Director of BioChromato, Inc.
  • Takashi Oonuki, Research Promotion Group, Group Director in Research Promotion Dept of Daiichi Sankyo RD Novare CO., LTD
  • Mutsuo Nakajima Former Senior Researcher of Sankyo Co., Ltd.

We will continue to devote ourselves to develop products based on customer’s voices. We kindly ask for your continued cooperation.


The detailed information is available here* on the website of Ministry of Education.
*We apologize as it is available in Japanese only.

BioChromato at ACS 2016 in Philadelphia



BioChromato exhibited at ACS 2016 in Philadelphia this past August 21-25. We had a great show with a steady traffic of Chemists.

Our lab consumables (EPS and Slit Seal) were on display. As well as our newest Mass spectrometry products, the ionRocket and Volatimeship. However, the star of the show was our Smart Evaporator (C1 and C10).

The Charm of the Smart Evaporator


We had many interesting and great conversations with many chemists from both industry and academia. We talked about the work they are doing and we discussed how our products may ease their work. We learned a lot from them.

Several of the chemists we spoke to are working in radiochemistry working with hazardous radioactive substances. The small size of the C1 impressed them as well as the ability to work inside a hot cell.


We also spoke to other chemists in medicinal chemistry working with small vials. They want to concentrate directly in their own sample vials. The C1 Smart Evaporator would be a great benefit for these researchers because the C1 allows direct concentrating in vials.

For synthetic organic chemists, being able to evaporate bump free is a major benefit. We heard a story about a 6 step synthesis process that resulted in a complete loss due to bumping caused by a Rotary Evaporator. A whole month’s work gone to waste.

We were also visited by many colleagues of happy customers that referred them to us. We continue to impress with its ability to evaporate bump free. Thereby reducing the risk of losing their material.

The Multi Channel Smart Evaporator


We had the Smart Evaporator C10 on display. People were able to see the multi-channel system. Their major takeaway: cross-contamination free between samples due to the vacuum technology.

There is also great interest in the C10 from teaching labs. Often, students are working on the same synthesis step and they have to fight over the only functioning Rotary Evaporator. Evaporating 10 samples at a time will reduce this bottleneck.

Thanks to everyone that stopped by. For those that were not able, we look forward to a conversation. Please feel free to contact us to learn more about how we can help streamline your research process.


Rotary Evaporator and Smart Evaporator

Rotary Evaporator

Differences between Rotary Evaporator and Smart Evaporator

Smart evaporator removes DMSO

Rotary evaporator is more efficient for most solvents. The Smart Evaporator evaporates and better removes high boiling point solvents such as DMSO, DMF and Water. Also, Smart Evaporator has advantages on small volume and precious samples regardless of the type of solution. A traditional Rotary Evaporator works better for others.

Rotary evaporators are used in chemistry laboratories for solvent removal. Including high boiling point solvents and sample concentration by using heat and vacuum. The Smart Evaporator is not intended to replace rotary evaporators. As rotary evaporators are still needed in many situations when concentrating samples. With the Smart Evaporator, you don’t need to worry about bumping during concentration of high boiling point samples. You may walk away during the concentrating process.

With a rotary evaporator, the solvent is under full vacuum to lower the boiling point. Heat is applied to the sample for the evaporation to occur. While effective, these conditions can lead to super-heating. This triggers rapid boiling, or “bumping” in your solvents. With the risk of cross-contamination upon bumping, this can lead to complete loss of the sample. Still, a rotary evaporator is a must have item for any organic chemistry lab. In conclusion, you need both types of evaporators.

No Bumping by Smart Evaporator

In contrast, the Smart Evaporator has no risk of bumping. There is no splashing in the evaporation process, since samples are never under full vacuum. Blowing is a common way to remove solvent. Putting a needle or pipette tip to a hose coming from a tank of inert gas such as helium, nitrogen, or argon gas. But, this method has drawbacks as well, as it is time consuming and leads to splashing. The Smart Evaporator provides a more elegant solution. By offering a hands-free evaporation process without the risk of bumping or splashing.