Prevent Sample Evaporation with a Plate Seal

RAPID Slit Seal™ is a plate seal designed for repeated LC/MS and autosampler sampling. Its pre-slit design provides easy sample access and returns after needle withdrawal, while the adhesive-free area above each well helps reduce adhesive contact and sample evaporation—helping preserve samples for next-day and repeated analysis.

Evidence from Published Research
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RAPID Slit Seal applied to a 96-well plate with the sealing sheet partially lifted

1. Insert

Pipette tip opening the pre-slit seal during insertion

2. Withdraw

Pre-slit seal returning toward its original position after withdrawal

Opens during sampling and returns toward its original position after withdrawal.


How RAPID Slit Seal™ Works

See how the pre-slit design provides sample access while helping limit evaporation and adhesive contact.

RAPID Slit Seal adhesive-free area above each well
ADHESIVE-FREE WELL AREA

No Adhesive Above Each Well

Adhesive is positioned around each well, leaving the well opening adhesive-free. This helps reduce adhesive contact with samples, pipette tips, and autosampler needles.

INSERT → WITHDRAW

Opens During Sampling and Returns After Withdrawal

The pre-cut slit opens during pipette or needle insertion, while the PET layer helps reduce friction. After withdrawal, the slit returns toward its original position, helping reduce evaporation between sampling steps.

RAPID Slit Seal opening during needle insertion and returning after withdrawal

Applications for RAPID Slit Seal™

  • ✓ HPLC & LC/MS — repeated sampling and analysis
  • ✓ Automated Pipetting & Liquid Handling — automated or repeated pipetting
  • ✓ Cell Culture & Incubation — microplate-based cell workflows
  • ✓ Biochemical Assays — plate-based assay workflows
  • ✓ DNA Extraction — microplate sample preparation
  • ✓ SPE & ADME — sample preparation and screening workflows
  • ✓ Automated Single Molecule Imaging — automated microplate imaging
  • ✓ Vortex Mixing — sealed plate mixing workflows

RAPID Slit Seal™ Specifications

Product RAPID Slit Seal™
Catalog No.
Outside the U.S. RSS-S96-80122 — 100 sheets / box
RSS-S96-10 — 10 sheets / box
U.S. R80.120.00 — 100 sheets / box
R80.120.10 — 10 sheets / box
Size 80 mm × 122 mm (96-well format)
Material PET, silicone
Adhesive Acrylic-based adhesive, with no adhesive directly above the well openings
Functional Temperature Range −80°C to +100°C
Instrument Use Examples Nano Space (Osaka Soda)
Shimadzu Prominence
Shimadzu Nexera i-Series LC-2040C 3D
Waters ACQUITY UPLC
CTC Analytics PAL-HTC
Agilent 1100 / 1200 / 1290 Series
ProteinSimple Maurice — cIEF applications
For ProteinSimple Maurice, plate seals are not recommended for CE-SDS applications.
PCR Compatibility No PCR inhibition
DNA-Free Certification Available on request. Contact us for details →
Need application instructions? View the RAPID Slit Seal™ Instruction Manual →

TRY RAPID SLIT SEAL™ IN YOUR WORKFLOW

Request a Free Sample

Use our contact form to request a RAPID Slit Seal™ sample. Product questions and application inquiries are also welcome.

Request a Free Sample

You will be directed to our general contact form.

RAPID Slit Seal™ vs. Common Plate Sealing Options

Plate sealing methods differ in sealing performance, repeated sample access, automation compatibility, and cost. For reusable options such as silicone mats, actual cost per use depends on reuse and cleaning requirements.

Solution Evaporation Prevention Repeated Sample Access Automation Compatibility Cost & Reuse
Conventional Adhesive Plate Seal Good Seal may need to be removed or peeled back Depends on seal type Typically single-use
Foil Seal Good Often intended for single use; piercing may leave an opening Depends on pierceability and instrument setup Typically single-use
Silicone Mat Good Pre-slit types can support repeated access Depends on mat and instrument setup Reusable; higher initial cost
RAPID Slit Seal™ Designed to reduce evaporation during repeated sampling No seal removal required for pipette or needle access Suitable for automated sampling workflows Single-use; lower cost than silicone mats

In-House Performance Testing

BioChromato evaluated RAPID Slit Seal™ on a 96-well plate to examine solvent evaporation before and after needle access.

Evaporation After Needle Access

Under the tested conditions, solvent loss was 7.7% before needle access and 8.2% after one needle insertion, indicating similar evaporation performance before and after access.

View Full Test Data →

Used in Published Research

RAPID Slit Seal™ has been referenced in published research. Bioz tracks citations and research use of laboratory products, providing an independent view of how the product has been used in scientific workflows.

Contact Us

TRY RAPID SLIT SEAL™ IN YOUR WORKFLOW

Request a Free Sample

Use our contact form to request a RAPID Slit Seal™ sample. Product questions and application inquiries are also welcome.

Request a Free Sample

You will be directed to our general contact form.

Frequently Asked Questions

Can RAPID Slit Seal™ be pierced with pipette tips or autosampler needles?
Yes. RAPID Slit Seal™ can be accessed with LC/MS or autosampler needles, pipette tips, and micropipettes. The pre-cut slit opens during insertion, allowing access to the sample without removing the entire plate seal.
What types of 96-well plates are compatible with RAPID Slit Seal™?
RAPID Slit Seal™ is designed for general SBS-standard microwell plates and is currently compatible with 96-well plates. Plates with a flat sealing surface are generally easier to adhere to and provide better sealability.
Does the adhesive contact the sample above each well?
No adhesive is positioned directly above the well openings. The adhesive is located around each well, helping reduce direct adhesive contact with the sample, pipette tip, or sampling needle during access.
Which autosamplers have been used with RAPID Slit Seal™?
Examples reported from BioChromato’s experience include Nano Space (Osaka Soda), Prominence (Shimadzu), ACQUITY UPLC (Waters), PAL-HTC (CTC), and Agilent 1100, 1200, and 1290 series systems. Instrument compatibility should be confirmed for each individual setup.
What is the functional temperature range of RAPID Slit Seal™?
The functional temperature range is -80°C to +100°C. Compatibility with the complete plate, sample, and instrument workflow should also be confirmed before use.
Can RAPID Slit Seal™ be autoclaved?
No. RAPID Slit Seal™ is not suitable for autoclave use and is not supplied as a sterilized product.
How should RAPID Slit Seal™ be stored?
Store RAPID Slit Seal™ at room temperature in a location that is not exposed to direct sunlight.
Can I request a free sample before purchasing?
Yes. Free RAPID Slit Seal™ samples are available for evaluation. Request a free sample →

Looking for more technical questions? View the full RAPID Slit Seal™ FAQ →

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Explore RAPID EPS →

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