Slit Seal, 96 well plate seal

Instant Self Closing Seal


The Slit Seal is a resistant, instant self-closing 96-well plate seal.
The adhesive-free, pre-cut slits made of silicone and PET allows easy insertion and withdrawal of pipette tips and sampling needles without catching and dragging.
The Slit Seal is proven to prevent solvent evaporation and cross-contamination. Acrylic-based adhesive is not above wells to prevent sample leaching. Seal can be easily applied and removed.
Suggested applications include automated pipetting and liquid handling, SPE, HPLC, LC/MS, cell culturing and ADME.

“We run quite a lot of samples with our mass spec, which is why some people in our lab prefer to use the autosampler plate for the samples so that they can just run 96 samples in one sitting…The plate seals are working perfectly for our application.”

Danica-Mae Manalo, Proteomics Lab, Cedars-Sinai Medical Center







  • Self-closes instantly
  • No cross-contamination between wells
  • Allows next day analysis
  • No adhesive on well spots
  • Pipette tips insert easily with less friction
  • Reduce solvent evaporation


  • Automated Single Molecule Imaging
  • Cell Culturing
  • BioChemical Assays
  • Incubation
  • Vortex
  • Automated Pipetting and Liquid
  • Handling
  • SPE
  • HPLC and LC/MS
  • ADME
  • DNA Extraction


  • Size: 80 mm x 122 mm (96-well format)
  • Material: PET, Silicone
  • Adhesive: Acrylic based (no adhesive over well spots)
  • Functional temperature range: -80°C to +100°C
  • No PCR inhibition
  • If DNA-free certification is needed, please contact us




Data Analysis Sheet

AirTightness to Acetonitrile and Water


Differences from Silicone Mats:

  • Pre-cut slits open easily, and PET layer reduces friction for very easy handling.
  • Lower cost than silicone mats.


Very Effective at Preventing Evaporation:

  • After 22 hours, 95% of 150 µl water will remain at 37°C
  • After 22 hours, 95% of 150 µl of Acetonitrile will remain at 4°C





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Ask, K. S., Lid, M., Øiestad, E. L., Pedersen-Bjergaard, S., & Gjelstad, A. (2019). Liquid-phase microextraction in 96-well plates-calibration and accurate quantification of pharmaceuticals in human plasma samples. Journal of Chromatography A.


Toth, C. A., Kuklenyik, Z., & Barr, J. R. (2019). Nuts and Bolts of Protein Quantification by Online Trypsin Digestion Coupled LC-MS/MS Analysis. In Functional Proteomics (pp. 295-311). Humana Press, New York, NY.


Berg, T., Eliassen, E., Jørgenrud, B., Kabashi, S., Petukhov, A., & Bogstrand, S. T. (2018). Determination of phosphatidylethanol 16: 0/18: 1 in whole blood by 96‐well supported liquid extraction and UHPLC‐MS/MS. Journal of Clinical Laboratory Analysis, e22631.


Yasui, M., Hiroshima, M., Kozuka, J., Sako, Y., & Ueda, M. (2018). Automated single-molecule imaging in living cells. Nature Communications, 9(1), 3061.