Those who have worked with DMSO (Dimethyl Sulfoxide) and DMF (Dimethylformamide) in organic synthesis and analytical chemistry are likely aware of the difficulty in evaporating and removing these useful, yet stubborn high boiling point solvents. Though using them may be dreaded and have even become a lost cause for others, this article outlines a way to remove these difficult solvents quickly and easily with the invention of new evaporation technology.
Due to their high solubility and ability to dissolve many compounds that are difficult to dissolve otherwise, DMSO and DMF are commonly used in organic synthesis as a reaction solvent as well as in analytical chemistry for NMR analysis (DMSO-D6, DMF-D7).
However, due the the high boiling points of these solvents (189°C for DMSO, 153°C for DMF) those who have worked with them after a synthetic workup or NMR analysis know they are difficult and time-consuming to remove using a traditional rotary evaporator, and have likely experienced problems such as bumping and having difficulty working with small samples.
Other methods to remove DMSO and DMF can prove to be time-consuming and inefficient as well. These methods include washing with water and extracting with a lower boiling point organic solvent like DCM1 and freeze drying (lyophilization) after water dilution or solid phase extraction (SPE). However, the large number of transfer steps and multiple washes are not only time-consuming, but are inefficient and result in lower yields and recovery rates.
With the goal of solving the problems associated with solvent evaporation, especially DMSO and DMF, the “Vacuum Vortex Evaporator,” also known as the Smart Evaporator, was invented to quickly and easily remove solvents without the common problems associated with traditional evaporation.
The key piece of technology in Vacuum Vortex Evaporation is the Spiral Plug, which creates spiral air flow and rapidly stirs solvents under heat and accelerates evaporation, even for high-boiling point solvents such as DMSO and DMF.
(You can read more details of its principal here.)
Using the nitrogen-purging feature, the Smart Evaporator can remove 5 mL of DMSO in just over an hour and DMF in just 24 minutes at 70°C.
The Smart Evaporator also provides the following benefits:
With Vacuum Vortex Evaporation using the Smart Evaporator, DMSO and DMF can be removed quickly and easily, without the hassles associated with standard evaporation methods. If you have any further questions regarding Smart Evaporator and working with DMSO and DMF, please use the contact form below and we will reply shortly.
All the best in your research and please let us know if we can help with your DMSO / DMF needs!