How can I remove DMSO from my sample?

To remove DMSO, a common method is to wash with water and extract with a lower boiling point organic solvent like DCM1. Other methods involve freeze drying (lyophilization) after water dilution or solid phase extraction (SPE). However, these methods involve several transfer steps, are very time consuming with multiple washes, and can be inefficient resulting in lower yields.


An easier way has been developed to evaporate high boiling point solvents like DMSO directly in your sample vial using the Smart Evaporator. The Smart Evaporator uses a novel concentration principle of solvent removal by spiral air flow with its unique Spiral Plug design. Since there is no sample transfer required, sample loss and risks of cross-contamination are minimized.

With its nitrogen purging feature, the Smart Evaporator can remove 5mL of DMSO in just over an hour at 70°C. In addition, since it is never under high vacuum, there is no risk of bumping, for hands-free concentration.
We introduce a simple way to remove Dimethyl Sulfoxide (DMSO). DMSO is used in organic synthesis as a reaction solvent as well as analytical chemistry for NMR analysis (DMSO-D6) due to its ability to dissolve many compounds that are difficult to dissolve otherwise. However, after a synthetic workup or NMR analysis, DMSO is difficult to remove using a traditional rotary evaporator due the the high boiling point (189°C).

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