Mr. Hiroshi Yamaguchi is specialized to research in the synthesis of radiopharmaceuticals, and he gives the great contribution for developing the early detection of CNS disease. We had an interview with him to find more about his usage of the Smart Evaporator in his research.
(Mr. Hiroshi Yamaguchi in Radiology Department of Research Institute for Brain and Blood Vessels-Akita, Akita Prefectural Hospital Organization)
I’m pleased to have this opportunity today.
It’s my pleasure too.
So, would you tell us about your research work?
The research field I’m working is the organic synthetic chemistry, and I study the synthesis of radiopharmaceuticals and their precursors. More precisely, I currently carry out the consideration of synthesis aiming for the imaging agent of the dopamine D3 receptor. The dopamine receptor is considered to relate with cranial nerve disease such as Parkinson’s disease or Alzheimer’s disease.
I’m working on the development research of imaging agents for the early detection of CNS desease.
I see. So how do you use our Smart Evaporator in your research?
The one usage is for the NMP evaporation. The NMP solution is firstly reacted, diluted with water by 10 times then refined with SepPak. We carry these operations for many times in our research. To improve the SepPak refining efficiency, 10cc of reacted solution is evaporated to 1cc before diluted with water. The NMP is a solvent with very high-boiling point(*1), so we could hardly evaporate that with a rotary evaporator. Your Smart Evaporator readily allows evaporation of NMP, which is extremely useful for us.
(*1: the boiling point of NMP is 204 Celsius)
Thank you very much! Do you have any other applications in your research?
The other is for evaporating the solution that contains (18F) fluorine ion. We can possibly evaporate that with a rotary evaporator, but will be exposed to radiation if we get close for monitoring. So we have to place that inside the hot cell (*2), but a rotary evaporator with a large footprint cannot be placed in the hot cell. I thank to the Smart Evaporator’s small footprint that can be installed in the hot cell.
(*2 The hot cell is a facility that securely ensures the shielding for handling radioactive materials.)
I’m glad to hear that. How do you find about its functionalities like evaporation speed?
I’m fully satisfied with the evaporation speed. I evaporate 1ml of solution with 20cc screw vials. I leave the evaporator running for a while even after the sample visually looks dried up since we are not willing to have any water left in the vial that may affect on reactions carried after evaporation. The fluorine isotope (18F) has a half-life of approximately 2 hours, so we need to evaporate that as soon as possible. The substance is not affected by heat so we shorten the evaporation speed by adding heat to 100 Celsius. We can finish up in 15 minutes, so it is pretty fast.
How interesting your application is. Do you think other researchers working in the radiopharmaceuticals use in the same way?
My colleague introduced me your evaporator at Annual Meeting of Pharmaceutical Society of Japan. He is also working in the same research field (radiopharmaceuticals) so he may also finds his application with your evaporator. Not in the basic research, but the pharmaceutical manufacturing requires the non-aseptic environment so it will need some special devices. For example in case of the radiopharmaceutical synthesis, the automated synthesizer is operated by remote control so if the Smart Evaporator is incorporated in such apparatus, I assume that would expand the possible applications.
I’m appreciated for the valuable opinions.
For the last question, why did you select the color “SUN”?
Simply that’s my favorite color. Also I thought it would delight the laboratory.
I see. Thank you very much for all your feedbacks, and we appreciate for your time today. We hope to continuously support you and your research work.
Mr. Hiroshi Yamaguchi uses the Smart Evaporator for evaporating the NMP solution and also the solution that contains (18F) fluorine ion after synthesis reaction. He’s been troubled to evaporate his subjected samples with a rotary evaporator, but the Smart Evaporator’s solved his situation, and we are all honored to partly contribute to the medical development.
(interviewer: Abe )
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