Rapid Microanalysis with ChemZo
Purpose
A method for the rapid measurement of trace components was investigated. This method involved transferring trace amounts of substances attached to a glass rod onto a preheated stainless steel POT.
Methods
| Ion Source | ChemZo (BioChromato) |
| Mass Spectrometer | compact QTOF (Bruker) |
| Measurement Method | A stainless steel POT was heated to 400°C, and a glass rod with the anti-inflammatory analgesic (loxoprofen) attached was brought into contact to check if ions could be detected. |
| Data Processing | The target ions were identified using Data Analysis (Bruker). |
Results
The TIC during measurement is shown in Fig.1. Although the sample attached to the glass rod is trace, when transferred to the stainless steel POT, protonated loxoprofen, ammonium ion adducts, and dimer ions were detected (Fig.2). Since the sample is in trace amounts, it does not contaminate the mass spectrometer, and because the stainless steel POT is heated, there is no carryover, allowing repeated measurements. Some of the possible applications include performing mass spectrometry directly on samples from thin-layer chromatography capillaries used to investigate organic synthesis reactions, or from samples measured by NMR.
