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Customer Review Vol. 5

“The Smart Evaporator has been useful for evaporating NMP. It is small and space-saving, so we can put it in a hot cell. I’m fully satisfied with the evaporation speed”

 



Hiroshi Yamaguchi studies radioisotope labeled medicine to find diseases at early stages in the CNS.
(Yamaguchi-san, Radiology, Akita Prefectural Hospital)


 

We are in the organic chemistry field. We synthesize radioactive medicine and its precursors. More specifically, we are trying to create dopamine D3 receptor imaging molecules. Dopamine receptors are thought to be related to Parkinson’s and Alzheimer’s disease.

In our research, we process samples dissolved in N-Methyl-2-pyrrolidone (NMP) and apply solid phase extraction (SPE). In order to use SPE effectively, we need to concentrate the original sample volume of 10 mL down to 1 mL before diluting with water. However, NMP has a high boiling point and a traditional rotary evaporator did not work at all. The Smart Evaporator is very useful because it works for high boiling point solvents such as NMP.

The other application is radiolabeled samples[18F] fluoride ion containing samples. It is possible to use a rotary evaporator for evaporation. However, we cannot stay next to it due to radiation exposure. We tried to install a rotary evaporator in a shielded hot cell, but the evaporator was too big and it did not work.  The Smart Evaporator is small and fits nicely in our hot cell. Thus, we use the Smart Evaporator to concentrate those samples.

I am happy with the speed of concentration.  The fluoride isotope we are working with has a 2 hour half-life, so we have to dry it off  as soon as possible.  Since it doesn’t break down by heat, we can apply 100ºC. It takes about 15 min to dry 1 mL samples in 20 mL vials. We can simply check the vial visually to ensure it completely removes the water from the sample vial.

I think the Smart Evaporator will be widely used in the field of radiology.  I was introduced to the Smart Evaporator by a colleague that was using it in the same manner.

The Smart Evaporator works great for research purposes.  In the future, I can see the potential usefulness in a production environment by automating the system in a sterilized environment. For example, the process in synthesizing radioisotope medicine would greatly benefit from such a system.

I chose the color sun red because I liked it! Labs require vibrant colors, you know.