I am responsible for synthesis of lead compounds and studies of synthesis for clinical trials. Because we use various types of solvents, it has been difficult to concentrate all with rotary evaporator only. With solvents such as DMSO and DMF, I could not concentrate samples at all with rotary evaporators. It was tedious and difficult to remove solvents from samples when analyzing micro volume impurities. With Smart Evaporator I am really happy to be able to concentrate samples in DMSO and DMF. Before using this, I had to repeat the same synthesizing process. Now, I can save a few days. It is a real shortcut for me!
One of my research themes is the synthesis of flavors. I need to remove all solvents before analysis because residual solvents influence on results. With rotary evaporators we ran into bumping risks. We also had difficulty removing residual solvents from eggplant flasks with negatively affected results. I appreciate the Smart Evaporator’s feature enabling me to use 2 ml vials directly, mild concentration, and bumping free.
I’m in charge of research of the Sustainable Jatropha Biofuel Production in Mozambique. The Smart Evaporator achieves fast evaporation and also accurate extraction of small volume. Many developing countries have frequent blackouts so it is very important that the time taken for research works remains short. Also, the apparatuses are usually handled by students who are not used to experiments and often damage the glassware. So the safe apparatus like the Smart Evaporator is valuable.
I research the synthesis and isolation of natural organic compounds. I’m researching biomarkers that quantitatively test the effect of disease diagnosis or medicines. When I tried to store samples in vials, the powdery samples would scatter by using the nitrogen blow down dry evaporator, which was troublesome. Then I saw the Smart Evaporator brochure, and found its high functionality and easy operation. Also the price was lower than expected so I made a decision right away. The Smart Evaporator C1 comes with good functionality and content and should be considered as an outstanding product.
The students were waiting for their turn to use the C1. Students prefer the Smart Evaporator because the evaporator is free from bumping. When I first saw the C10 at a conference, I had already made my mind. Once I had the budget ready, I decided to buy without hesitation. When setting up the vials and the Spiral Plugs, it’s smooth to lift up and down the heating block, I found it’s far easier than the C1.
I work with fungus of microorganisms. First I extract the fungus components, then refine and identify the target components from them. At our company, researchers shared centrifugal evaporators, but many times it was occupied by others and contamination of different samples was a concern. We own two units of Smart Evaporator for different purposes and use them almost every day. To avoid oxidization I usually purge with gas. This function has been helpful for sample storage.
The Smart Evaporator allows me to concentrate my samples into vials in less time with no mess—even DMSO and DMF. Very convenient!
Our laboratory works on research to clarify the energy transduction mechanism of photosynthesis. We concentrate samples to complete dry. We used to try this with the rotary evaporator, but the same process took hours since we were not able to add heat and the water did not readily evaporate. Also, most of the sample stayed on the inner surface of the flask resulting in a huge sample loss. With the Smart Evaporator, the process requires less than ten minutes. We can have more measurements so we can have better data with higher reliability. Also the footprint of the apparatus becomes less than half compared to others. Our laboratory now improves the analysis efficiency, and the Smart Evaporator is an invaluable asset.
Dr. Tatsuya Tomo
Our company operates in various areas like electronic fields or chemical fields. I mainly work on the material development which applies for our coating as well as chemical technology. I generally handle polymers and for synthesis I use the Smart Evaporator as a “small-sized Rotary Evaporator”. The Smart Evaporator does not need sample transfer and is also bump-free. So I just leave it and do something else, then the evaporation is done. I also thank the integrated heater, I can even set the temperature to 40 Celsius but still readily evaporate samples. This laboratory basically works under the nitrogen environment, so I had to confirm the ability to purge gas. And it can be installed anywhere due to its small size.
My research is in organic synthesis of antibiotics and biologically active substances from plants. I use low boiling solvents such as methylene chloride and ethyl acetate. The Smart Evaporator is easy to use because it is free from bumping, its unclosed system and compact size. I am happy with the ease of sample collection due to the flexibility for various types of containers. For example, I use centrifuge tubes for recrystallization, which I cannot use with other evaporators. Moreover, aluminum beads hold containers firmly, which relaxes me.
Professor Takuya Kumamoto
I search the effective application of light or energy and expand that idea to create new materials or improve current materials. We use such materials to develop new products. I use the Smart Evaporator for concentrating samples for synthesis or excluding solvents before measurement. I generally concentrate water and also other solvents like isopropyl or acetone. I completely dry up the small quantity solvent like 5 ml or 10 ml, and for synthesis or analysis I use the same sample tubes sized 10 ml, 20 ml, or 50 ml. We used to take more than a half day to concentrate water, but now we just have to leave for 2 hours after it’s started. This brings us a great improvement in our work efficiency.
I’m working on the polyphenol research. With NMR we analyze the pigments extracted from natural products and also study their functions. Before using Smart Evaporator, I had a difficulty in concentrating DMSO sample with freeze drying. Then, I needed to dilute samples with water and to use ODS cartridge, then to transfer them into volatile solvents. To be honest, I was worried about the effect of the solvent transfer on samples. However, now I am free from the worries thanks to efficient concentration with Smart Evaporator. I was amazed with the concentration speed of DMF at 40℃. It took less than 1 hour to concentrate 1 ml of DMF in 10 ml glass tube, 10 ml vial and 25 ml egg plant flask, which was impossible to concentrate with rotary evaporator.
This is a revolutionary idea, and I’ve been amazed with how convenient this is. Our research is on polymer synthesis. We analyze it under certain environment which differs from the ordinary environment. We use the Smart Evaporator for drying up samples. It’s useful for evaporating 2 ml to 3 ml of water from the sample tubes sized 20 ml or 30 ml. I used to use a hotplate or oven, but we had to keep our eyes on the samples to avoid overheating. The sample tubes are handy for weight measurement as well as for liquid chromatography after drying up. So the Smart Evaporator, which allows evaporation with the preferred containers has been a huge advantage for our ease.
I’m working in organic synthetic chemistry. I study the synthesis of radio-pharmaceuticals and their precursors. Smart Evaporator has been useful for evaporating NMP. It is small and space-saving, so we can put it in a hot cell. I’m fully satisfied with the evaporation speed. I evaporate 1 ml of solution with 20 cc screw vials. I leave the evaporator running for a while even after the sample looks dried up. We are not willing to have any water left in the vial that may affect on reactions carried after evaporation. We can finish up in 15 minutes, so it is pretty fast.
Mr. Hiroshi Yamaguchi
Our research is in surface chemistry, one of the subjected research materials is the surfactant solution. With the rotary evaporator it was difficult to simplify the evaporation process, and we used to have a wide variation in results. One of the issues was bumping, and we had to transfer the samples from eggplant flask to vials for storage. Even the students who are not used to organic synthesis can use the Smart Evaporator, and its simple operation brings a stable evaporation result. The Smart Evaporator is able to concentrate the surfactant solutions even those with high viscosity, and anyone can operate in a short time effectively.
User Voice Vol. 1
We visited a lab where we had provided a demo Smart Evaporator unit. The researcher was worried about concentrating high boiling point solutions such as DMSO and DMF (Natural Product Chemistry Lab at a University) DMSO was removed in 1 hour at 40°C. This is great!
Biochromato: Can you tell us about your research?
Mr. M: We are looking at polyphenol. We extract pigments from Natural Products and then analyze the pigment’s NMR and functionality.
Bio: How did you learn about the Smart Evaporator? Mr. M: Your distributor initially introduced Single Flex (previous model).
Bio: Did you demo Single Flex?
Mr. M: Yes, we tested it with DMSO samples. However, we did not purchase Single Flex.
Bio: What were the issues?
Mr. M: It did not work well at room temperature and without heating.
Bio: So then you tested Smart Evaporator because it has a built-in heater, correct?
Mr. M: Correct. We set it at 40 ºC and could remove the DMSO. Smart Evaporator eliminated our problem and we thank you for it.
Bio: Thank you for the compliment. It is normally hard to remove DMSO, isn’t it?
Mr. M: We have previously been using a lyophilizer to remove DMSO from the samples. However, it did not work so well because, I guess, DMSO saturated in the vial and dissolved back. Then we tried adding water and run through solid phase extraction with C18 cartridge and dissolve the target compounds in another solvent. I was worried about the effects of the solvent to the sample. Smart Evaporator worked well to concentrate DMSO and made our life easy.
Bio: Do you use it for any other application?
Mr. M: We are also using it to concentrate DMF. We dispense 1 mL DMF in 10 cm test tubes, 10 mL vial, 25 mL flasks at 40ºC. In case of rotary evaporator, it could not evaporate completely even after 2 hours. With the Smart Evaporator, DMF is completely gone within a short amount of time. This is great!
Bio: Lastly, any request or comment to us?
Mr. M: It is advantages to be able to use various vials but we would like to use one optimal vial. It would be great if we could run 4 vials at once.
Bio: Thank you for your comments. We really appreciate it.
User Voice Vol. 2
We visited and asked the story until purchase of Smart Evaporator. (Chemical Biology Lab at a University)
Could remove DMSO!
Biochromato: How did you hear about the Smart Evaporator?
T: Your distributor brought us the smart evaporator brochure.
Bio: What feature drew your attention?
T: The possibility to concentrate DMSO samples. It is normally so hard to evaporate DMSO. I thought it would be so great to evaporate DMSO.
Bio: What do you think after using Smart Evaporator?
T: It works exactly as the brochure say, which is wonderful.
Bio: There are many types of concentrators on the market. What did you find beneficial from the Smart
T: We just purchased it is so it’s hard to say. However, the advantages are on type of samples, volume and number of vials. Rotary evaporators are good for larger volumes and centrifugal types are good for large number of vials and having small volume samples. We would like to use Smart Evaporator for concentrating DMSO or similar. There are advantage and disadvantage for each product. We need to keep several tools for each specific occasion.
Bio: I see. Are you going to keep using our Smart Evaporator?
T: Actually, we only use it once a week. However, it does help our research.
Bio: Thank you. Do you have any comments or request to us?
T: We once splashed the liquid, but it was probably because we had too much volume. It is a bit difficult to adjust the valve. I am good at it now though. Also, it would be great if we can run several samples at once.
B: Thank you for your comments. We will develop even better products.
User Voice Vol. 3
For the organic chemist, concentrating samples is a very important process. We visited an Organic Chemistry Lab. Their research is focusing on the basis of functional material development. We interviewed the user Mr. I
who has been using the Smart Evaporator.
Can store samples in the same vials.
Biochromato: First, what point of our product are you mostly interested in?
I: Regardless the type of sample vial, it allows you to concentrate your samples. We actually borrowed a demo unit of the previous model.
Bio: I see. Why you did not purchase at that time?
I: I had to prepare a heater at that time. It is not so complicated but I just felt it would be too tedious. Now the heater is integrated to the evaporator, which satisfied me. Then I bought it again and decided to try it.
Bio: Thank you. What do you think of it after using it?
I: It is great that I can keep the sample in the same vial I can concentrate my sample in. After synthesis in a flask, the flasks take a lot of space and we have limited numbers flasks. We then have to transfer the samples to sample vials and concentrate. In the case of rotary evaporator, it is not easy to connect small vials directly to the joint so we place a small vial in a bigger sample vial. We had to tweak vial configurations. The Smart Evaporator did not need such tedious steps. We could use the storage vial with the Smart Evaporator.
Bio: Thank you for the compliment. Do you think other researchers have the same problem with the rotary evaporator?
I: Yes, if they are organic chemists. I had to tweak a little bit at any lab I have been working for.
Bio: I see. It is a great comment. Thank you.
User Voice Vol. 4
This time we visited Yamaguchi-san who is studying radioisotope labeled medicine to find a disease at early stages in the CNS. (Yamaguchi-san, Radiology, Akita Prefectural Hospital)
Biochromato: Could you tell me about your study?
Y: We are in the organic chemistry field. We synthesize radioactive medicine and its precursors. More specifically, we are trying to create dopamine D3 receptor imaging molecules. Dopamine receptors are thought to be related to Parkinson’s and Alzheimer’s disease.
B: Thank you. How are you using the Smart Evaporator?
Y: One thing is concentrating N-Meytl-2-Pirolydone (NMP). During our research, we process the NMP solution and dilute the sample 10 times of volume and apply to solid phase extraction (SPE). In order to use SPE effectively, we need to concentrate the original sample volume of 10 ml to 1 ml before diluting with water. However, NMP has high boiling point and rotary evaporator did not work at all. Smart Evaporator is very useful because it works for high boiling point samples.
B: I am very happy to hear that. Thank you. Is there any other application you use it for?
Y: The other one is [18F] fluoride ion containing samples. It is possible to use rotary evaporator for those. However, we cannot stay next to it because we will be exposed to radiation. Then the rotary evaporator has to be installed in a shielded hot cell and the evaporator is too big. Smart Evaporator is small and fits in the hot cell. Thus we use Smart Evaporator for those samples, too.
B: I am very happy to hear the story. Are you satisfied with the concentration speed?
Y: Yes, I am. We put 1 ml samples in the 20 ml screw vials. After concentrating, we have to remove water completely in the vial. So we just check the sample vial visually then keep the vacuum pump running for a while until it completely dries. Fluoride isotope has 2 hours half-life. We have to make it dry as soon as possible. It cannot break down by heat and we can apply 100ºC. It takes about 15 min to dry.
B: It is very interesting application. Do you think the Smart Evaporator will be widely used in the radiology field?
Y: Yes. Another researcher was using it in the same way and he introduced it to me. Smart Evaporator works fine in the basic research area but it may not be applied to the production protocol because it is required to process all steps in a sterilized environment. For example, at the process of synthesis of radioisotope medicine, it is common to use automated synthesis system controlled by a PC. If your product could be used in that process, the needs of your product would extend.
B: Thank you for your suggestion. At last, may I ask why you chose color of SUN?
Y: Just because I liked it. Labs require a vivid color, you know.